Biokesum S&R

PRE CLINICAL RESEARCH

Protective effects with 100mg/kg of BioKesum™ and do not show scopolamine induced deficit in learning and memory (equivalent to donepezil) and Gingko biloba. This effect is further validated in two clinical trials looking into cognitive function and memory in healthy subjects

Reference:

George A, Ng CP, O'Callaghan M, Jensen GS, Wong HJ. In vitro and ex-vivo cellular antioxidant protection and cognitive enhancing effects of an extract of Polygonum minus Huds demonstrated in a Barnes Maze animal model for memory and learning. BMC Complement Altern Med. 2014 May 19;14:161. doi: 10.1186/1472-6882-14-161.

CLINICAL RESEARCH

Product

BioKesum™ 

CRO

UKM, Malaysia

 Study Design

Randomized, Double- Blind, Placebo- controlled

Dosage

250mg per capsule: 2 capsule/day

No. of Subjects

40 (20 per arm)

Age group

≥ 35 and ≤59 years old

Supplementation duration

6 weeks

Primary Objective

·         To determine the efficacy of BioKesum™ on cognitive function of middle age adults by using validated cognitive assessments (CNSVS, WASI, RAVLT, CTMT, POMS, SF-36)

·         Safety bioprofile and Adverse Event Analysis

Results

·         favourable mean changes observed in group  BioKesum™ compared to placebo for cognitive functions (graph 1) and psychosocial assessment (graph 2)

·         Groups experiencing good mood (POMS>15) showed significant intervention effect (p<0.05) for short term memory

·         Groups experiencing bad mood (POMS<15) showed significant intervention effect (p<0.05) in IQ and social functioning

·         Safe (no difference between and placebo).

Study 2:

 

Product

BioKesum™  (ingredient in product called SuperUlam)

CRO

Medicus, US

 Study Design

Randomized, Double- Blind, Placebo- controlled, arm- crossover

Dosage

150mg per capsule: 2 tablets before test (1 time supplementation)

No. of Subjects

20 subjects x 2 (crossover)= 40

Age group

≥ 35 and ≤65 years old

Study duration

7 days

Objectives

 

·         To investigate improvements in attention through a battery of cognitive tests (CNSVS System) and mood changes (Profile Mood of States, POMS Questionnaires)

·         Adverse Event Analysis

Results

•      Neurostimulatory and neurocognitive performance enhancement effect impacting various aspects of cognition and memory at different times between 1 and 5 hours after a single dose

•      Safe (no difference between and placebo).

References:

Study 1: Shahar S, Aziz AF, Ismail SNA, et al. The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: a randomized, double-blind, placebo-controlled study. Clinical Interventions in Aging. 2015;10:1505-1520. doi:10.2147/CIA.S86411.

Study 2: Jay K Udani, “Effects of SuperUlam on Supporting Concentration and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 238454, 10 pages, 2013. doi:10.1155/2013/238454

HIGH IN ANTIOXIDANT

Kesum have been shown to have the highest total phenolic content amongst other 'Ulam' (salad) plants (Maizura, et. al., 2011). BioKesum shows strong antioxidant properties that slow the oxidative processes and free radical damage such as:

Reference:

Maizura, M., Aminah, A. and Wan Aida, W. M. Total phenolic content and antioxidant activity of kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. International Food Research Journal 18: 529-534 (2011).

George A, Ng CP, O'Callaghan M, Jensen GS, Wong HJ. In vitro and ex-vivo cellular antioxidant protection and cognitive enhancing effects of an extract of Polygonum minus Huds (Lineminus™) demonstrated in a Barnes Maze animal model for memory and learning. BMC Complement Altern Med. 2014 May 19;14:161. doi: 10.1186/1472-6882-14-161.